Overview
The CIP (Clean-in-Place) & SIP (Sterilize-in-Place) System is an automated cleaningand sterilization solution designed for pharmaceutical, biotechnology, vaccine, cosmetic,food, and beverage manufacturing facilities. It enables effective cleaning and sterilizationof process equipment, pipelines, storage tanks, reactors, fermenters, vessels,homogenizers, heat exchangers, and filling systems without dismantling the equipment.
The system ensures complete removal of product residues, contaminants, andmicroorganisms while minimizing downtime, reducing manual intervention, andmaintaining full compliance with cGMP, WHO, US FDA, ISPE, and ASME BPE guidelines.-
Key Features
• Fully Automatic PLC & HMI Controlled Operation
• Single, Double, or Multi-Tank Configuration
• Automatic Cleaning Recipe Selection
• Automatic Chemical Dosing
• Pure Steam Sterilization
• Programmable Cleaning Cycles
• Hygienic SS316L Construction
• Orbital Welded Sanitary Piping
• Automatic Temperature Control
• Automatic Flow & Pressure Control
• Conductivity-Based Rinse Verification
• Data Logging & Batch Reporting
• Recipe Management
• SCADA Integration Available
• 21 CFR Part 11 Compliance (Optional)
• Compact Skid Mounted Design
• Easy Validation & Qualification -
Process Flow
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Applications
Suitable for cleaning and sterilizing:
• Mixing Vessels
• Manufacturing Reactors
• Fermenters
• Bioreactors
• Storage Tanks
• Process Pipelines
• Homogenizers
• Heat Exchangers
• Filters & Filter Housings
• Filling Machines
• Transfer Lines
• WFI Distribution Loops
• Syrup Manufacturing Systems
• Injectable Processing Equipment -
Technical Specifications
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Standard Cleaning Sequence
1. Pre-Rinse
2. Caustic Wash
3. Intermediate Rinse
4. Acid Wash (Optional)
5. Final Rinse
6. Conductivity Verification
7. Drain
8. Steam Sterilization
9. Cooling
10. Ready for Production -
Optional Features
• Recovery CIP System
• Loss-Type CIP System
• Mobile CIP Unit
• Multi-Use Cleaning Circuits
• Automatic Chemical Concentration Control
• Conductivity Monitoring
• TOC Monitoring
• Heat Exchanger
• Pure Steam Generator Integration
• Recipe-Based Operation
• • Remote Monitoring
• SCADA System
• 21 CFR Part 11 Software
• Barcode Batch Tracking
• Automatic Validation Reports -
Advantages
• Fully Automated Cleaning & Sterilization
• Reduced Production Downtime
• Lower Water & Chemical Consumption
• Improved Product Safety
• Consistent Cleaning Performance
• Reduced Human Error
• Enhanced Equipment Life
• Faster Batch Changeover
• Easy Validation
• Energy Efficient Operation
• Reduced Maintenance Cost
• Compliance with Global Regulatory Standards -
Compliance
Designed in accordance with:
• cGMP
• WHO Guidelines
• US FDA Requirements
• EU GMP
• ISPE Baseline Guides
• ASME BPE
• GAMP 5
• 21 CFR Part 11 (Optional)
• IQ, OQ & PQ Documentation Support -
Typical System Configuration
The complete system typically includes:
• CIP Solution Tanks
• Purified Water / WFI Tank
• Acid & Caustic Tanks
• Pure Steam Supply Line
• Hygienic Pumps
• Plate Heat Exchanger
• Pneumatic Valve Manifold
• Flow, Pressure & Conductivity Instruments
• PLC & HMI Control Panel
• Automated Piping & Valve Network
• Return Line & Recovery System
• Optional SCADA Workstation -
Industries Served
• Pharmaceutical Manufacturing
• Biotechnology
• Vaccine Production
• Injectable Manufacturing
• API Manufacturing
• Cosmetics & Personal Care
• Food & Beverage Processing
• Dairy Industry
• Nutraceutical Manufacturing
• Research & Development Laboratories
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Key Benefits
• Validated and repeatable cleaning and sterilization cycles
• Automated operation with recipe-based process control
• Hygienic design for contamination-free production
• Reduced manual labor and operational costs
• Seamless integration with existing pharmaceutical process equipment
• Designed for high reliability, easy maintenance, and long service life
• Available in custom configurations to meet specific plant capacities and processrequirements
