Stirred Tank Reactors for API Synthesis, Chemical Processing & Batch Reactions
Pharmaceutical reactors — also known as stirred tank reactors (STRs) or agitated process vessels — are jacketed pressure vessels used to carry out chemical synthesis, crystallization, extraction, hydrogenation, and other unit operations in bulk drug (API) and formulation manufacturing. Constructed to cGMP and ASME standards, they combine precise agitation with controlled heating or cooling to ensure consistent reaction kinetics, yield, and product quality across every batch.
-
Key Features
• Contact parts in SS316L / SS316 / Hastelloy for corrosive or high-purity applications; SS304 for utility duty
• Half-pipe coil, dimple, or conventional jacket for heating (steam/hot oil) and cooling (chilled water/brine)
• Interchangeable agitator options — anchor, turbine, propeller, or paddle — matched to process rheology
• Mechanical seal or magnetic-drive agitator shaft sealing to prevent product contamination or vapor loss
• Top or bottom entry manways, sight glass, and multiple process/instrumentation nozzles
• PLC/HMI-based automation with recipe management, batch data logging, and 21 CFR Part 11 support
• CIP/SIP-compatible design with spray balls and self-draining bottom dish for easy cleaning validation -
Typical Applications
• Bulk drug (API) synthesis, crystallization, and salt formation reactions
• Solvent extraction, distillation feed preparation, and hydrogenation (with pressure-rated design)
• Intermediate and formulation-stage mixing, dissolution, and reaction quenching -
Technical Specifications
