Bioreactors for Microbial & Cell Culture-Based Production
Fermenters, or bioreactors, provide a sterile, controlled environment for the cultivation of bacteria, yeast, fungi, or mammalian cells to produce antibiotics, enzymes, vaccines, recombinant proteins, and other biologics. Precise control of temperature, pH, dissolved oxygen, and agitation — combined with an in-place sterilisable (SIP) design — allows reproducible, contamination-free fermentation from lab and pilot scale through full commercial production.
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Key Features
• SS316L polished internal surfaces (Ra ≤ 0.4 µm) for cleanability and reduced microbial adhesion
• In-situ sterilisable (SIP) and clean-in-place (CIP) design with spray-ball coverage validation
• Rushton turbine / pitched-blade agitators with baffles for optimal oxygen transfer (kLa)
• Ring or micro-sparger for sterile air/oxygen delivery; exhaust gas condenser and filter
• Online pH, dissolved oxygen (DO), temperature, foam, and pressure sensors with auto-control
• Jacket or internal coil for both sterilisation heating and process cooling
• Sample valve, sight glass with light, and addition ports for inoculum/nutrient feed -
Typical Applications
• Antibiotic and enzyme fermentation (e.g., penicillin, amylase, protease production)
• Recombinant protein and vaccine antigen production using microbial or mammalian cell lines
• Seed and inoculum development, scale-up studies, and process development runs -
Technical Specifications
